Limited Use Label Licenses

Limited Use Label License No: 406 GeneArt® Precision TAL Effector Products

Limited Use Label License 406:

Notice to Purchaser: The purchase of this product conveys to the buyer the limited, non-transferable right to use this product and components of the product only to perform internal research for the sole benefit of the buyer. The buyer may also use standard molecular biology techniques to make additional copies of this product for purposes of internal research for the sole benefit of the buyer but the buyer may not modify the sequence of the TAL Effector in the product. Notwithstanding the foregoing, the buyer may not use this product, its components or materials or cells made using this product or its components to generate any animal without obtaining additional rights from Life Technologies. The buyer cannot sell or otherwise transfer (a) this product, (b) its components, or (c) materials, cells, or organisms made using this product or its components (including but not limited to Plants in all cases hereunder) to a third party, or otherwise use this product, its components, or materials, cells, or organisms made using this product or its components for any Commercial Purpose or Development Purpose with the sole exception that buyer may transfer this product, its components, and/or materials, cells, or organisms made using this product or its components to (i) the buyer’s legal affiliates and/or (ii) a scientific collaborator, provided that each such legal affiliate and/or, scientific collaborator agrees in writing (1) not to transfer such product, its components, or materials, cells, or organisms made using such product or its components to any third party, and (2) to use such product, its components, and materials, cells, and organisms made using such product and/or its components solely for research as set forth in this limited use label license and not for Commercial Purposes or Development Purposes. If this product is subject to multiple limited use label licenses, the terms of the most restrictive limited use label license shall control.

Mice generated using this product may be donated to The Jackson Laboratory by not-for-profit buyers, and by for-profit buyers who have obtained the additional rights noted in the preceding paragraph. Please include a copy of this limited use label license with all donations to identify the TAL Effector Technology used.

“Commercial Purpose” means any activity for consideration, including but not limited to: (a) any use, directly or indirectly, in manufacturing, production, or quality control; (b) any use to provide a service, information, or data; (c) any use for therapeutic, diagnostic or prophylactic purposes; or (d) any sale, resale, leasing, or licensing, whether or not for research purposes.

“Development Purpose” means any: (a) activity in a Phase l or later clinical trial; (b) activity in any agricultural field trial, including any such field trial that would be subject to regulation by the United States Department of Agriculture if the plants were to constitute genetically engineered organisms under 7 C.F.R. § 340 (or any successor regulation); (c) activity directed towards the submission of data to the United States Food and Drug Administration, the United States Department of Agriculture, the United States Environmental Protection Agency, or any equivalent regulatory agency outside of the United States, in support of an application for clearance, approval or deregulation by such agency; (d) cell line development, for the purpose of bioproduction; (e) screening or profiling of more than 10,000 distinct compounds (high-throughput screening); and/or (f) scale-up activities, the primary focus of which is to increase from small-scale to production-scale.

“Plant” means any plant, plant tissues or plant cells, including green algae, but does not include fungi or blue-green algae, generated by use of this product, or any progeny (propagated through any number of generations) or unmodified derivatives of such plants, tissues or cells.

For information on obtaining additional rights to TAL Effector Technology for any use not permitted herein, except use in Plants, please contact outlicensing@thermofisher.com, Licensing and Commercial Supply, Thermo Fisher Scientific, 5823 Newton Drive, Carlsbad, CA, 92008, United States.

For information on obtaining additional rights to TAL Effector Technology for any use in Plants not permitted herein, please contact Two Blades Foundation at info@2blades.org or Two Blades Foundation, 1630 Chicago Avenue, Suite 1907, Evanston, IL 60201 USA.

For information on donating mice to The Jackson Laboratory, please visit their website at: http://www.jax.org/grc/index.html.